动物菌 (Bifidobacterium animalis) 的亚种. 乳糖BLa80通过调节干细胞因子 (SCF) /c-Kit通路和肠道微生物群来缓解小鼠的便秘
Zhaochun Zhang1, Jie Li1, Ziyi Wan1
1State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. zm0102@tust.edu.cn.
Food & function
|February 24, 2025
概括
生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BLa80在患有便秘的小鼠中显示出显著的松作用. 这种益生菌通过增强肠道运动,保持便水分和平衡肠道微生物群来改善肠道健康.
科学领域:
- 微生物学和肠道健康
- 胃肠病学 胃肠病学
- 功能性食品 功能性食品
背景情况:
- 益生菌作为健康成分越来越受到关注,但它们的具体作用,如松,以及机制尚未完全理解.
- 益生菌物种的多样性需要对其生理影响进行详细的研究.
研究的目的:
- 为了研究Bifidobacterium animalis亚种的液作用. 功能性便秘小鼠模型中的乳糖BLa80.
- 阐明BLa80对胃肠道作用的潜在机制.
主要方法:
- 一个功能性便秘的小鼠模型被诱导使用洛佩拉米德化物.
- 小鼠接受了不同剂量的BLa80,盐水对照剂或莫萨普里德 (阳性对照剂) 的治疗.
- 分析包括体重,便含水量,肠道通行,结肠组织学,微生物组成 (16S rRNA测序),血清标记物和基因表达 (RT-qPCR).
主要成果:
- BLa80显著加快了肠周平静,改善了便中的水含量.
- 益生菌预防了肠道屏障损伤,增加了有益的短链脂肪酸,并纠正了肠道微生物群失调.
- BLa80调节了关键神经递质 (5-HT,MTL,SP) 和与粘液产生 (MUC2),肠道运动 (c-Kit,SCF) 和水运输 (AQPs) 相关的基因表达.
结论:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BLa80在小鼠中表现出强大的抗便秘作用.
- 它的机制包括增强肠道运动性,保持屏障功能,调节肠道微生物群和相关信号通路.
- BLa80显示出作为功能性食品的新兴成分,以缓解便秘为目标,并作为潜在的治疗替代品.
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Microbiota of the Large Intestine
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Functions of the Gut Microbiota
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


