使用标准化查协议对肺癌患者静脉血栓栓塞的前性评估
Pedro Magalhães Ferreira1, Joana Ferreira1, Cláudia Freitas2
1Pulmonology Department, University Hospital Center of São João, Porto.
概括
在肺癌患者中,静脉血栓塞栓症 (VTE) 的积极查显示发生率为15.7%. D-二次体水平和风险评分改善了VTE预测,这表明目前的发病率估计被低估了.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 静脉血栓栓塞 (VTE) 是癌症患者的一个重大问题,肺癌患者面临高风险.
- 目前的肺癌VTE发病率数据往往不一致,可能低估了真正的患病率.
研究的目的:
- 评估查方案对新诊断的肺癌患者VTE发病率和风险因素的影响.
- 评估预测生物标志物和风险分层工具对VTE在这个人群中的有用性.
主要方法:
- 对102名新诊断的肺癌患者进行前性队列研究.
- 标准化VTE查方案,包括凝血测试,D-二次体水平和成像 (超声波,CT) 在基线和3个月.
- 对风险因素,生物标志物 (D-二次体) 和风险评分 (Khorana) 进行分析,以预测VTE.
主要成果:
- 诊断出VTE发生率为15.7%.
- 在男性,COPD患者,转移性疾病患者,特别是接受免疫治疗的患者中,VTE更为常见.
- 基线和3个月D-二聚合物水平升高与VTE有显著的关联.
- 3个月后的D-二元度,结合Khorana得分,改善了治疗患者的静脉瘤风险预测.
结论:
- 积极的VTE查显著增加了诊断率,这表明新诊断的肺癌中VTE发病率被低估了.
- 在肺癌患者中,D-二聚体水平是VTE的有价值的预测生物标志物.
- 对VTE的风险评估工具可以通过结合D-二极管测量来增强.
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