无载体的Cisplatin-Dactolisib纳米颗粒用于增强协同作用的抗瘤有效性
Mei Zhang1,2, Qiuxia Tan3, Sevil Gonca2
1School of Engineering, Institute for Materials and Processes, University of Edinburgh, Robert Stevenson Road, Edinburgh EH9 3FB, U.K.
ACS biomaterials science & engineering
|February 24, 2025
概括
这项研究开发了新型纳米粒子,将西斯 (CDDP) 与达克托利西布 (BEZ) 结合起来,以增强癌症治疗. 这些纳米粒子有效地向癌细胞,增加有效性并减少瘤转移.
科学领域:
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 西斯 (CDDP) 是一种广泛使用的化疗药物,但其有效性受到副作用,耐药性和转移的限制.
- 将CDDP与其他药物结合在一起是克服这些局限性的策略.
研究的目的:
- 通过将其与PI3K/mTOR双抑制剂达克托利西布 (BEZ) 结合起来,增强西斯丁 (CDDP) 的抗瘤功效.
- 开发使用自组装CDDP-BEZ纳米粒子 (NP) 的无载体代码交付系统.
主要方法:
- 合成的CDDP-BEZ纳米粒子具有pH响应性,用于向药物输送.
- 在实验室中评估了CDDP-BEZNP的细胞毒性,DNA损伤,亡诱导和PI3K/mTOR信号抑制.
- 在体外和体内评估了CDDP-BEZNP的抗转移作用.
主要成果:
- 由于药物的协同作用,CDDP-BEZ NPs在癌细胞中表现出增强的细胞毒性.
- 这些纳米粒子有效地诱导了DNA损伤和线粒体依赖的亡.
- 在体外和体内观察到显著抑制瘤迁移和转移.
- 结合疗法有效抑制了PI3K/mTOR信号轴.
结论:
- CDDP-BEZ NPs代表了一个安全有效的平台,用于最大限度地提高癌症治疗中的药物协同作用.
- 这种方法提供了一个有前途的策略,通过将其与PI3K抑制剂结合起来来提高基化疗药物的治疗疗效.
更多相关视频
07:20Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
13.9K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.4K
相关概念视频
Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
