卵巢粘膜瘤中的FOXA1表达及其与粘素表达及其与KRAS突变的关联:对瘤进展和分化的影响
Men Yuan1, Harumi Saeki2, Takuo Hayashi1
1Department of Human Pathology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Virchows Archiv : an international journal of pathology
|February 24, 2025
概括
叉头盒A1 (FOXA1) 在卵巢粘膜瘤中常见表达,与粘素表达相关. 它与KRAS突变的同时发生可能导致瘤进展和肠道分化.
科学领域:
- 妇科瘤学 妇科瘤学
- 分子病理学分子病理学
- 瘤生物学 瘤生物学
背景情况:
- 叉头盒A1 (FOXA1) 是一种转录因子,与上皮细胞的发育和分化有关.
- 卵巢粘膜瘤中FOXA1的作用,特别是与粘素表达和KRAS突变的关联,需要进一步阐明.
- 了解这些关系对于澄清FOXA1在卵巢瘤进展和分化中的参与至关重要.
研究的目的:
- 为了研究卵巢粘膜瘤中的分叉盒A1 (FOXA1) 表达模式.
- 评估FOXA1表达,粘素表达 (MUC2,MUC5AC,MUC6) 和KRAS突变状态之间的关联.
- 为了澄清FOXA1在粘膜卵巢瘤的进展和分化中的作用.
主要方法:
- 免疫组织化学被用来分析FOXA1,MUC2,MUC5AC和MUC6表达在57个正常/良性组织和324个卵巢上皮瘤 (110个粘膜,214个其他) 中.
- 在瘤样本上进行了KRAS突变分析.
- 进行了统计分析,以确定标记物和临床病理特征之间的关联.
主要成果:
- 在正常的卵巢表皮和布伦纳瘤中观察到强烈的核FOXA1染色.
- FOXA1的表达与粘膜组织学有显著的关联,并且随着粘膜瘤的等级 (囊瘤到癌瘤) 逐渐增加.
- MUC2表达和KRAS突变也显示出恶性瘤增加的趋势,KRAS突变丰富在FOXA1阴性细胞瘤中. 福克斯A1表达和KRAS突变显示从囊瘤逐步增加到癌症.
结论:
- 粘性卵巢瘤经常表达FOXA1,表达水平与瘤等级相关.
- KRAS突变和FOXA1表达的同时发生似乎是粘膜卵巢瘤肠道分化和进展的重要因素.
- 福克斯A1可以作为一种有价值的生物标志物,以了解粘膜性卵巢瘤的病变发生.
相关概念视频
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K


