饮食中酸盐降血压作用的个体间差异:一个随机的双盲,安慰剂控制的复制交叉试验
Eleanor Hayes1,2, Shatha Alhulaefi1,3, Mario Siervo4,5
1Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
European journal of nutrition
|February 24, 2025
概括
酸盐补充剂对氧化 (NO) 和血压 (BP) 有影响,但个体之间的反应有很大差异. 需要进一步的研究来理解这些NO生物标志物和BP的个体间差异.
科学领域:
- 心血管生理学心血管生理学
- 营养生物化学 营养生物化学
背景情况:
- 已知食酸盐补充剂可以增加氧化 (NO) 的生物可用性,从而降低血压 (BP).
- 然而,个体对酸盐补充剂的反应程度有所不同,这是以前没有在强大的研究设计中探索的因素.
- 这项研究旨在调查这些反应在个人中的一致性,并量化个人间的差异.
研究的目的:
- 检查氧化物 (NO) 生物标志物和血压 (BP) 上食酸盐补充剂影响的个体内一致性.
- 量化对酸盐饮食生理反应的个体间差异.
主要方法:
- 一个复制的交叉设计被采用了15名健康的男性参与四次实验室访问.
- 参与者饮用了富含酸盐或缺乏酸盐的甜菜汁,在摄入后测量了酸盐/酸盐和血血压.
- 统计分析包括复制相关性和混合效应模型,以评估响应变异性.
主要成果:
- 与安慰剂相比,富含酸盐的甜菜汁显著增加了血中酸盐和酸盐的水平,并降低了心压 (平均:-7mmHg) 和心压 (平均:-6mmHg) 血压.
- 观察到显著的个体间变异性,缩血压反应的变异性估计在±7mmHg.
- 在复制品之间发现了血酸盐,酸盐和缩血压之间的中等至大相关性 (r=0.55至0.91).
结论:
- 食中酸盐补充剂对NO生物标志物和缩血压的生理影响具有显著的个体间差异.
- 这种参与者特定变化的根本原因需要进一步调查.
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