系统性炎症反应指数是否可以作为新诊断高血压患者非滴滴模式的标记?
Mustafa Kaplangoray1, Kenan Toprak2, Cuneyt Caglayan3
1Cardiology Department, Acıbadem Eskişehir Hospital, Eskişehir, Turkey. mkaplangoray@gmail.com.
Cardiovascular toxicology
|February 24, 2025
概括
系统性炎症反应指数 (SIRI) 可以预测非浸泡性高血压 (NDHT). 在非浸泡性高血压患者中发现了较高的SIRI水平,这表明其作为诊断标记物的潜力.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 高血压研究 高血压研究
背景情况:
- 系统性炎症反应指数 (SIRI) 与冠状动脉疾病和心力衰竭等心血管疾病的结果有关.
- 非浸泡性高血压 (NDHT),一种异常血压下降的模式,与心血管风险增加有关.
- 调查用于识别NDHT的新生物标志物对于风险分层和管理至关重要.
研究的目的:
- 在新诊断的高血压患者中,评估系统性炎症反应指数 (SIRI) 和非滴滴高血压 (NDHT) 之间的关联.
- 确定SIRI是否可以作为NDHT的独立预测器.
- 将SIRI的诊断性能与NDHT的其他炎症和心血管风险标志物进行比较.
主要方法:
- 一项对254名新诊断高血压患者进行的回顾性研究,这些患者接受了门诊血压监测 (ABPM).
- 患者被分为滴水 (DHT) 和非滴水 (NDHT) 组.
- 使用中性粒细胞,单细胞和淋巴细胞计数来计算SIRI. 其他标记包括MHR,NLR,PLR,CRP,HDL-C和LVMI.
主要成果:
- 与DHT组相比,NDHT组的SIRI,MHR,NLR,PLR,CRP和中性粒细胞数量显著增加.
- 相反,HDL-C和淋巴细胞计数在NDHT组较低.
- 多变量分析确定SIRI,LVMI和HDL-C作为NDHT的独立预测因素. 与其他指数相比,SIRI在预测NDHT方面表现出更高的区分能力.
结论:
- SIRI 是一个独立且显著的非浸泡性高血压预测因子.
- 系统性炎症反应指数显示,与MHR,NLR,PLR,HDL-C和LVMI相比,NDHT识别的诊断性能优越.
- 在临床实践中,SIRI可以作为一种有价值,易于获取的生物标志物来检测NDHT.
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