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相关概念视频

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Updated: May 26, 2025

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在转移中循环瘤微环境.

Rui Tang1, Shujuan Luo2, Hui Liu3

  • 1Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.

Cancer research
|February 24, 2025
PubMed
概括

循环瘤微环境 (cTME) 显著影响癌症转移,影响循环瘤细胞 (CTC) 存活和扩散. 了解cTME为癌症治疗提供了新的治疗点和生物标志物.

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科学领域:

  • 在瘤学瘤学.
  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.

背景情况:

  • 癌症转移是癌症相关死亡的主要原因.
  • 循环瘤细胞 (CTC) 在转移期间面临着许多挑战.
  • 循环瘤微环境 (cTME) 极大地影响了CTC的命运.

研究的目的:

  • 审查了解cTME的最新进展.
  • 突出生物物理线索和组件在cTME中的作用.
  • 探索cTME作为治疗标和生物标记物的潜力.

主要方法:

  • 关于cTME的最近研究的文献综述.
  • 对cTME的生物物理线索,细胞和非细胞组件的分析.
  • 在cTME中综合有关生物角色和网络相互作用的信息.

主要成果:

  • 该cTME是一个动态的液体微环境,与初级或前转移性区不同.
  • 生物物理属性,血液细胞和非血液因素在cTME中相互作用.
  • 在cTME中的特定组件和线索影响CTC存活率和转移.

结论:

  • 在调节癌症转移方面,cTME起着至关重要的作用.
  • 针对cTME是一个有希望的策略,可以抑制转移.
  • cTME具有作为预测患者结果的生物标志物的潜力.