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Sabine Karam^1,2, Ala Ali³, Winston Fung⁴

¹Division of Nephrology and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, Minneapolis.

|February 24, 2025

概括

免疫疗法改善了癌症的生存率,但可能导致脏损伤. 早期诊断和管理炎和细胞因子释放综合征等毒性,对于保持功能和患者的结果至关重要.

科学领域:

在瘤学瘤学.
腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学

背景情况:

由于免疫疗法,包括免疫检查点抑制剂和CAR T细胞疗法,癌症生存率有所改善.
这些新的癌症治疗可以导致系统性炎症毒性,影响功能.
与免疫疗法相关的不良事件可能会限制治疗疗效,并构成危及生命的风险.

研究的目的:

审查现代免疫疗法与脏相关的毒性.
强调这些不良事件的及时诊断和管理的重要性.
突出在接受免疫治疗的癌症患者中维护功能的策略.

主要方法:

关于与免疫检查点抑制剂和CAR T细胞治疗相关的不良事件的文献综述.
对这些治疗引起的损伤机制的分析.
讨论临床表现,诊断和管理策略.

主要成果:

免疫检查点抑制剂通常会导致急性间歇性炎,可能导致治疗中止.
卡尔-T细胞疗法可以诱导细胞因子释放综合征和免疫效应细胞相关的血细胞性淋巴组织细胞,导致损伤.
这些与免疫相关的不良事件可以表现为各种病理.

结论:

脏毒性是癌症免疫疗法的重要并发症.
及时识别和干预对于管理这些不良事件至关重要.
有效的管理可以保持功能,并改善癌症护理中的整体患者结果.

关键词:

艾基 (AKI) 是一个人.临床科临床科药物毒性药物毒性

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