周围血液中的表观遗传年龄加速与脑-MRI年龄加速相关
Pedro Sant'Anna Barbosa Ferreira1, Jenny van Dongen1,2, Anouk den Braber1,3,4
1Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands.
Brain : a journal of neurology
|February 24, 2025
概括
来自DNA甲基化和大脑结构的生物衰老标记预测健康结果. 环境因素显著影响加速衰老,这表明生活方式干预可能是有效的.
科学领域:
- 老年学是指老年学的学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经成像是一种神经成像.
背景情况:
- 全球人口老龄化,与年龄相关的疾病的患病率增加.
- 生物衰老标志物,包括DNA甲基化和大脑结构,显示出预测健康结果的潜力.
- 了解这些生物标志物之间的相互作用对于开发有效的健康干预措施至关重要.
研究的目的:
- 为了研究DNA甲基化年龄加速和大脑年龄加速之间的关联.
- 使用双胞胎模型检查对这些协会的遗传和环境贡献.
主要方法:
- 分析了254名来自荷兰双胞胎登记册的参与者 (20-84岁).
- 使用五个表观遗传时钟 (Hannum,Horvath,PhenoAge,GrimAge,DunedinPACE) 对DNA甲基化年龄加速的评估.
- 使用神经成像 (brainageR) 评估大脑衰老加速.
- 应用双变双胞胎模型,包括交叉双胞胎交叉特征相关性和单胞胎 (MZ) 双胞胎对差异.
主要成果:
- 在DNA甲基化年龄加速 (Hannum和GrimAge时钟) 和大脑年龄加速之间发现了显著的关系.
- 在MZ内双胞胎对差异建模支持这些观察到的关系.
- 交叉双胞胎交叉特征建模表明,这些协会没有共同的环境病因.
结论:
- 双胞胎分析强调了环境因素在加速衰老中的重要作用.
- 这些发现表明,针对生活方式修改的干预措施可能有利于缓解加速衰老.
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