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精神病药物对COVID-19死亡的保护作用在疫苗之前的死亡率
Rodrigo Machado-Vieira1, Trudy M Krause2, Gregory Jones1
1Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
PloS one
|February 24, 2025
概括
在2020年的一项研究中,精神病药物,特别是抗抑郁药,与COVID-19严重程度的降低有关. 长期使用者显示,严重后果的可能性降低了9%,这表明这些药物具有潜在的保护作用.
科学领域:
- 流行病学 流行病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 新冠肺炎 (COVID-19) 疫情构成了重大的公共卫生挑战,精神疾病被确定为感染和疾病严重性的潜在风险因素.
- 了解预先存在的疾病和治疗对COVID-19结果的影响对于患者管理至关重要.
研究的目的:
- 调查特定精神病药物使用与COVID-19结果之间的关联,包括感染可能性和疾病严重程度.
- 在COVID-19疫苗普及之前检查这些关系.
主要方法:
- 这是一项使用Optum非标识化的Clinformatics Data Mart数据库进行的横截面研究.
- 包括2020年被诊断为COVID-19的患者及其在美国的精神病药物处方数据.
- 对人口统计因素和并发症进行调整的有序后勤回归分析,以预测COVID-19的严重程度.
主要成果:
- 与非使用者相比,长期使用精神药物的患者患COVID-19严重程度较高的可能性降低了9%.
- 选择性色素再吸收抑制剂 (SSRI) 抗抑郁药的使用者,无论是长期还是短期,都显示出更低的COVID-19严重程度的可能性明显更高.
- 在不同的药物类别和使用时间 (长期和短期) 中观察到结果的变化.
结论:
- 精神药理学药物似乎与COVID-19严重程度的降低有关.
- 抗抑郁药物,特别是SSRI,可能会对严重的COVID-19结果产生保护作用.
- 需要进一步的研究来阐明这些观察到的关联背后的机制.
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