血中三甲度与失脂血症风险之间的关联:全国代表性的跨部分研究
Zi-Hao Xu1, Xu-Lian Tang1, Hong-Xuan Huang1
1Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Environmental science & technology
|February 24, 2025
概括
暴露于消毒副产品,特别是三甲 (THM),与增加脂质失调风险有关. 这项研究发现,高血THM水平与成年人患脂质障碍症的几率更高有关.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 消毒副产品 (DBPs) 在实验研究中与改变的脂质合成有关.
- 有限的流行病学证据将DBPs与脂质障碍症联系在一起.
- 三甲 (THM) 是饮用水中常见的DBP.
研究的目的:
- 为了调查血液THM暴露和失脂症风险之间的关联.
- 分析2005-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 检查特定的THM,包括甲 (TCM),二甲 (BDCM),二甲 (DBCM) 和甲 (TBM).
主要方法:
- 利用了2005-2018年NHANES中16159名成年人的数据.
- 采用多变量逻辑回归来评估失脂症风险.
- 应用加权量子总和 (WQS) 回归和量子G计算用于混合物分析.
主要成果:
- 血中TCM,BDCM,TBM和总THM (TTHMs) 度的升高与失脂症风险的增加显著相关.
- 对于最高的THM组,调整后的赔率比率 (ORs) 从1.23到1.35不等.
- 关联在年轻和中年人群中更为明显.
- 综合THM暴露显示出与失脂症风险的积极关联.
结论:
- 血液THM度与失脂血症的风险有关.
- 调查结果表明,THM暴露存在潜在的环境健康风险.
- 需要进一步的研究来证实这些发现并阐明生物机制.
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