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Updated: May 26, 2025

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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葡萄糖类-1受体激活剂和患有2型糖尿病的老年人抑郁症的风险:一个向试验仿真研究

Huilin Tang1, Ying Lu1, William T Donahoo2

  • 1Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, Gainesville, Florida (H.T., Y.L.).

Annals of internal medicine
|February 24, 2025
PubMed
概括

与DPP4is相比,类似葡萄糖-1受体激动剂 (GLP-1RAs) 在患有2型糖尿病的老年人中显示出抑郁症的风险略低,但与SGLT2is不同. 这一发现有助于理解GLP-1RA在管理T2D和心理健康方面的影响.

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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
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