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在商用织品中通过以效果为导向的分析识别一种阿里碳化合物受体agonistic分散染料

Iwaki Nishi¹, Taichi Yoshitomi¹, Fumi Nakano¹

¹Division of Chemistry, Kanagawa Prefectural Institute of Public Health, 1-3-1 Shimomachiya, Chigasaki, Kanagawa, 253-0087, Japan.

|February 24, 2025

概括

织品可能含有基碳化合物受体 (AhR) 激动剂. 这项研究确定了Disperse Violet 93:1,Disperse Blue 291和Disperse Blue 373作为织品中的AhR激动剂,需要进一步评估健康风险.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
分析化学分析化学

背景情况:

织品含有各种化学物质,使安全评估复杂化.
织品中的阿里碳化合物受体 (AhR) 激动剂尽管存在潜在的健康影响,但仍未得到充分研究.

研究的目的:

调查织品中AhR激动剂的存在和身份.
评估特定分散染料的AhR激活潜力.

主要方法:

以效果为导向的分析 (EDA) 结合了基于细胞的测定 (AhR-luciferase reporter) 和化学分析.
液体染色学与Orbitrap-液体染色学/质谱学 (MS) 结合,用于化合物识别.
确定激动剂的剂量反应评估.

主要成果:

十分之二的织品表现出显著的AhR激活活性.
在一个织品中,Disperse Violet 93:1被确定为一种强大的AhR激动剂.
分散蓝291和分散蓝373最近被确定为AhR激动剂.

结论:

织品可能是暴露于激活AhR的分散染料的来源.
特定激动剂的鉴定使得未来的暴露和毒性评估成为可能.
进一步的研究至关重要,以了解与织品中的AhR激动剂相关的健康风险.

关键词:

阿里碳水化合物受体是什么?分散染料是一种分散染料.以结果为导向的分析.织品织品织品织品

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