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在肝细胞癌的局部和系统疗法的组合

Bin-Yan Zhong¹, Wenzhe Fan², Justin J Guan³

¹Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China; Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

The lancet. Gastroenterology & hepatology

|February 24, 2025

概括

地方区域疗法对于肝细胞癌治疗至关重要. 将这些与免疫治疗相结合可能会改善患者的治疗结果和安全性,提供新的治疗策略.

科学领域:

肝胆道癌症肝胆道癌症
干预性瘤学干预性瘤学
免疫治疗是一种免疫疗法.

背景情况:

地方区域疗法 (LRT) 是早期到局部晚期肝细胞癌 (HCC) 的标准.
新兴的基于免疫疗法的全身疗法正在影响HCC的治疗范式.
随着新的全身治疗选择,LRTs的作用在不断变化.

研究的目的:

审查当前关于HCC局部区域和全身疗法的数据.
讨论关于局部和全身疗法的结合证据.
专注于组合治疗方法的协同效果和安全性.

主要方法:

对HCC治疗方法的现有文献进行系统审查.
对临床研究的分析,研究了合并的局部区域和全身治疗.
来自组合治疗试验的疗效和安全数据的评估.

主要成果:

地方区域疗法仍然是HCC管理的基石.
免疫疗法显示出有希望的结果,但挑战了现有的治疗策略.
结合的局部区域和全身疗法显示出改善结果的潜力.

结论:

结合的局部和全身疗法可以在HCC治疗中提供协同效益.
需要进一步的研究来优化组合策略,以提高有效性和安全性.
这种方法代表了管理晚期肝细胞癌的有希望的途径.

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