在长期COVID疲劳中,震和肌肉纤维传导速度
João Aris Kouyoumdjian1, Leticia Akemi Rama Yamamoto1, Carla Renata Graca1
1Faculdade Estadual de Medicina de São José do Rio Preto (FAMERP), Departamento de Ciências Neurológicas, Psiquiatria e Psicologia Médica, Laboratório de Investigação Neuromuscular, São José do Rio Preto SP, Brazil.
Arquivos de neuro-psiquiatria
|February 24, 2025
概括
在长期COVID (LC) 患者中,疲劳/后劳动不适很普遍. 电生理学研究发现神经肌肉连接功能或肌肉纤维传导速度没有显著异常,这表明这些不是LC疲劳的主要因素.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 生理学 生理学 生理学
背景情况:
- 长期COVID (LC) 被定义为SARS-CoV-2感染后3个月的持续症状.
- 疲劳/后劳动不适 (F-PEM) 影响高达70%的LC患者,无论最初的感染严重程度如何.
- 了解像F-PEM这样的LC症状的生理基础至关重要.
研究的目的:
- 在长期COVID中调查神经肌肉结 (NMJ) 功能.
- 在长期COVID患者中评估孤立肌肉纤维传导速度 (MFCV).
- 为了比较LC患者与没有F-PEM和健康对照之间的电生理学发现.
主要方法:
- 单纤维电肌图 (评估动) 在前肌进行.
- 测量了肌肉纤维传导速度 (MFCV) 和快到慢的MFCV比率 (F/S比率).
- 在37个对照组和32例SARS-CoV-2病例 (16 LC-yes, 16 LC-no) 中,通过针状肌电图分析了运动单元潜力 (MUP).
主要成果:
- 在对照组,LC-no组和LC-yes组之间没有观察到动参数的显著差异.
- 在任何参与者群体中,MFCV,F/S比率和MUP都没有显示出异常.
- 疲劳/后劳动不适 (F-PEM) 是最常见的症状,在所有LC-yes患者中都存在.
结论:
- 疲劳/压力后不适是研究的长期COVID病例中的普遍症状.
- 电生理学评估没有确定神经肌肉结或肌肉纤维是导致长期COVID疲劳/F-PEM的重要因素.
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