在一般人群中用维生素D强化面包的有效性和潜在毒性:一个预测建模研究
Bahareh Nikooyeh1, Michael F Holick2, Zahra Abdollahi3
1Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The Journal of nutrition
|February 24, 2025
概括
用维生素D强化小麦粉可以改善人口健康. 每100克面包250 IU的剂量有效地提高了维生素D水平,没有毒性风险.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 食品的强化 食品的强化
背景情况:
- 维生素D缺乏是严重的公共卫生问题.
- 麦粉强化提供了一种可行的策略,以提高一般人群的维生素D摄入量.
- 从强化中排除糖果制品和重的面包需要有针对性的方法.
研究的目的:
- 开发一种对维生素D强化面包有效性的预测模型.
- 评估各种强化剂量对人口维生素D状态的影响.
- 为了确定与不同维生素D强化水平相关的潜在风险.
主要方法:
- 一项横截面研究调查了Birjand和Yazd的1051名个人 (7-65岁).
- 通过24小时回忆收集人口统计,人体测量和实验室数据,以及面包消费数据.
- 一个模拟模型评估了不同剂量的维生素D (IU/100g面包) 对25-基硫醇[25(OH) D]水平的影响.
主要成果:
- 基线数据显示,维生素D缺乏 (37.5%的儿童,37.4%的成年人) 和缺乏 (34.7%的儿童,31.8%的成年人) 的高率.
- 250 IU/100g面包的强化剂量显示出改善人口维生素D状态的显著潜力.
- 500 IU/100g的剂量在70%以上的人群中达到足够的25(OH) D,在400 IU/100g时达到有害水平的风险是最小的 (0.1%).
结论:
- 在每100克面包中添加250-350国际单位维生素D,可以提高超过一半的人群的维生素D状况.
- 这种强化范围确保了足够的维生素D水平,而不会造成严重的毒性风险.
- 麦粉强化为广泛使用的维生素D补充剂提供了一种实用且安全的方法.
相关概念视频
Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Probability Laws
39.6K
Overview
39.6K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
295
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
295


