评估三十年来腹腔大动脉动脉瘤患者的心血管风险和药物管理
Samira E M van Knippenberg1, Niels J S Thiermann2, Morsal Atazadah2
1Department of Surgery, Amsterdam University Medical Centres, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
概括
患有腹腔大动脉动脉瘤 (AAA) 的患者随着时间的推移,心血管风险和诊断的增加. 诊断时处方药物的不充分使用凸显了改善心血管风险管理的需要,以降低死亡率.
科学领域:
- 血管外科 血管外科
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 腹腔大动脉瘤 (AAA) 与心血管风险和死亡率的增加有关.
- 了解并发症和药物治疗的趋势对于管理AAA患者的治疗结果至关重要.
研究的目的:
- 分析随着时间的推移,AAA患者的心血管并发症和药物处方的趋势.
- 评估这些因素与全因死亡率的关联.
主要方法:
- 从1989年到2023年,对7957名AAA患者进行了回顾性队列研究.
- 在诊断时对6个时间段的并发症和药物的评估.
- 多变量考克斯比例危险模型用于死亡率分析.
主要成果:
- 随着时间的推移,心血管并发症 (高血压,TIA,MI) 和药物使用 (抗血小板药物,β-阻断剂,他类药物) 增加.
- 老年,慢性功能衰竭,心力衰竭和COPD与较高的死亡率有关.
- 失脂血症,抗血小板和酸盐使用与死亡率降低有关.
结论:
- AAA患者的人口统计和并发症概况已经转向更高的心血管风险.
- 目前在AAA诊断时的心血管风险管理似乎不足.
- 需要加强心血管风险管理策略,以减少AAA相关的死亡率.
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