在接受采用细胞疗法的固体瘤患者中感染
Viswatej Avutu1, Jumanah N Algazaq2, Kenneth Seier3
1Department of Medicine, Sarcoma Medical Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.
Transplantation and cellular therapy
|February 24, 2025
概括
固体瘤采用细胞疗法 (ACT) 后的感染比血液癌症更少. 感染的关键风险因素包括表现不佳的状态和托西利祖马布的使用.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 传染病流行病学 传染病流行病学
背景情况:
- 采用细胞疗法 (ACT) 是一个不断增长的癌症治疗模式.
- 传染性并发症在血液性恶性瘤中得到了充分证实,但在固体瘤中不那么明显.
- 关于接受ACT的实体瘤患者感染流行病学的数据有限.
研究的目的:
- 描述成年实体瘤患者在ACT后180天内感染的流行病学.
- 为了确定与ACT后感染发展相关的风险因素.
主要方法:
- 来自132名成年实体瘤患者的回顾性数据收集,这些患者接受了ACT治疗.
- 感染被跟踪从ACT输液一天到输液后的180天.
- 用单变量和多变量分析来确定风险因素.
主要成果:
- 21.2%的患者在30天内感染,13%在31-180.天之间感染.
- 细菌感染是最常见的;病毒和真菌感染是罕见的.
- 东部合作瘤学集团 (ECOG) 绩效状态 (PS) ≥2和托西利祖马布接收是感染的独立风险因素.
结论:
- 在ACT后的固体瘤患者的感染率低于血液恶性瘤的感染率.
- 病毒/真菌感染的低发病率表明,抗菌/抗真菌预防可能没有益处.
- ECOG PS和托西利祖马布的使用是感染的重要预测因素,表明患者的脆弱性.
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