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Updated: Jun 15, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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使用菌体显示器向蛋白-蛋白相互作用的共价循环抑制剂的识别

Sijie Wang1, Franco F Faucher2, Matilde Bertolini3

  • 1Department of Pathology, School of Medicine, Stanford University, Stanford, California 94305, United States.

Journal of the American Chemical Society
|February 24, 2025
PubMed
概括

研究人员开发了一种新方法来发现向蛋白质相互作用的共价宏循环药物. 这种方法确定了针对SARS-CoV-2的不可逆转的抗病毒化合物,突出显示了长期治疗效果的潜力.

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相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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