绿色传感器技术:使用日期内核衍生的碳点量化carbidopa和eltrombopag
Rana Ghonim1,2, Amira F El-Yazbi1, Heba Elmansi3
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexanderia University, Alexanderia, Egypt.
Phytochemical analysis : PCA
|February 24, 2025
概括
这项研究引入了一种新的,环保的碳点传感器,用于检测卡比多巴和eltrombopag. 开发的方法提供了一种快速而敏感的方法,用于在各种样本中量化药物.
科学领域:
- 新的传感技术是新的传感技术.
- 绿色化学的应用绿色化学的应用
- 基于纳米材料的药物检测.
背景情况:
- 开发一种使用可食废物回收的新型传感技术.
- 微波激光溶解枣和氨酸,以创建碳点 (CD).
- 应用CD作为传感器探针用于药物定量.
研究的目的:
- 使用可分辨关闭的光纳米传感器量化carbidopa (CAR) 和eltrombopag (ELT).
- 在纳米维度水平上检测CAR和ELT.
- 开发一种环保且快速的分析方法.
主要方法:
- 使用多功能光谱技术进行表征.
- 药物检测的光谱度测试灭方法.
- 使用AGREE准备和复杂的GAPI指标对环境影响的评估.
主要成果:
- 观察到CAR和ELT的静态火与硫和日期核碳点 (S,NDKCDs).
- 具有特定激发和辐射波长的高量子输出率 (53%).
- 在定义范围内的精确量化,具有高回收率和低相对标准偏差.
结论:
- 经过验证的方法符合ICH Q2 (R1) 准则.
- 成功量化纯形式的CAR和ELT,药物制剂和人体血.
- 在开发的传感方法中证明了出色的绿色度指标.
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