与年龄相关的嗅觉敏感性下降,对9种不同的分子进行选择
Agnieszka Sabiniewicz1, Malaika Krause2, Thomas Hummel2
1Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany. a.sabiniewicz@gmail.com.
概括
嗅觉灵敏度随着年龄的增长而下降,特别是对于更重的分子. 这项研究调查了不同气味物体间与年龄相关的气味感知差异,揭示了基于年龄和分子重量的显著差异.
科学领域:
- 嗅觉神经科学是一种神经科学.
- 老年学是一门学科.
- 感官感知是一种感官感知.
背景情况:
- 嗅觉功能自然会随着年龄的增长而下降.
- 然而,这种下降不均,并可能受到诸如"成功老化"和特定气味特性等因素的影响.
- 以前的研究表明,某些分子更容易受到与年龄相关的嗅觉损失的影响.
研究的目的:
- 为了前性地研究和比较年轻人和老年人的气味值.
- 检查不同气味特性对与年龄相关的嗅觉敏感性的影响.
- 要确定与年龄相关的嗅觉衰退是否是分子特异性的.
主要方法:
- 一项前性研究涉及58名参与者,其中31%的年龄为50岁或以上.
- 对一个由九种不同的气味剂组成的面板的气味检测值的评估.
- 使用通用线性混合模型 (GLMM) 评估年龄和分子量效应的统计分析.
主要成果:
- 与老年人相比,年轻的成年人表现出明显更高的气味敏感性,不管是什么气味.
- 分子重量影响了所有年龄组的气味值,较轻的分子产生更高的灵敏度.
- 在分子量和年龄组之间没有发现显著的相互作用,这表明与年龄相关的衰退不仅仅取决于这个队列中的分子量.
结论:
- 气味值通常随着年龄的增长而下降,在较高分子量化合物中观察到更明显的效应.
- 与之前的一些发现相反,这项研究没有发现证据表明,与年龄相关的嗅觉衰退对于测试组内的特定分子来说显著地更为明显.
- 这些发现表明,虽然年龄和分子量是嗅觉感知的关键因素,但气味下降的特异性可能取决于所选择的分子组.
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