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METS-IR指数和阻塞性睡眠呼吸暂停之间的关联:来自NHANES的证据

Huangyi Yin¹, Wei Huang², Bijun Yang³

¹Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Scientific reports

|February 24, 2025

概括

胰岛素抵抗代谢评分 (METS-IR) 与阻塞性睡眠呼吸暂停 (OSA) 的更高患病率有关. 与其他胰岛素抵抗指数相比,METS-IR还显示了OSA的优异诊断准确性.

科学领域:

代谢综合征和睡眠医学
心血管健康和内分泌学

背景情况:

胰岛素抵抗 (IR) 是阻塞性睡眠呼吸暂停 (OSA) 的已知危险因素.
胰岛素耐药性代谢评分 (METS-IR) 是一种新型指数,与OSA相关,尚未得到广泛研究.

研究的目的:

调查METS-IR指数与OSA的患病率之间的关联.
为了比较METS-IR的诊断准确度与其他已建立的OSAIR指数.

主要方法:

利用了2005-2008年和2015-2018年国家健康和营养检查调查 (NHANES) 的数据.
采用后勤回归模型和限制立方线 (RCS) 曲线来分析METS-IR,其他IR指数 (TG/HDL-C,TyG,HOMA-IR) 和OSA患病率之间的关系.
使用接收器操作特征 (ROC) 曲线和进行的子组分析评估诊断值.

主要成果:

总共有8306名参与者被纳入,OSA的患病率为30.69%.
经过调整后的分析显示,METS-IR,TG/HDL-C,TyG指数和HOMA-IR与OSA患病率之间存在显著的积极关联.
与METS-IR的最低三分之一相比,METS-IR的最高三分之一显示OSA的几率增加了2.96倍. 对于OSA,METS-IR显示了最高的诊断准确度 (AUC = 0.652).

结论:

METS-IR指数与OSA患病率有积极的关联.
与HOMA-IR,TG/HDL-C和TyG指数相比,METS-IR显示了OSA的优越诊断性能.
虽然各个子组的关联是稳定的,但在所有IR指数中观察到与糖尿病的显著相互作用.

关键词:

横截面研究横截面研究胰岛素耐药性胰岛素耐药性是一种这就是METS-IR的意义.尼汉斯 (NHANES) 是一个名人.在OSA中使用OSA.

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