生殖因素与脆弱风险之间的关联:来自英国生物库的基于人口的分析
Tongmin Chang1, Zengle Zhao2, Xiaoyan Liu3
1Clinical Epidemiology Unit, Qilu Hospital of Shandong University, 107 Wenhua West Road, Jinan, 250012, Shandong, China.
BMC public health
|February 24, 2025
概括
早期初潮和第一次活产的年龄较小增加了老年妇女的脆弱风险,而更高的平价是保护性的. 生殖因素显著影响脆弱性.
科学领域:
- 老年学是指老年学的学科.
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,生殖因素与女性未来的脆弱性之间存在联系.
- 有限的证据需要进一步调查特定的生殖因素及其与老年妇女脆弱的关联.
研究的目的:
- 探索各种生殖因素与老年妇女脆弱的风险之间的联系.
- 确定特定的生殖特征是否有助于增加脆弱风险.
主要方法:
- 利用了来自238,555名女性参与者的英国生物库数据.
- 通过自我报告的数据评估生殖因素和脆弱性指标.
- 采用二项逻辑回归,对共变量进行调整,并进行分层和灵敏度分析.
主要成果:
- 早期初潮 (年龄<12岁) 与较高的虚弱风险相关 (OR: 1.118).
- 第一次活产时的年龄较小 (<21岁) 增加了虚弱的风险 (OR: 1.057).
- 较高的平价显示了脆弱性风险降低 (OR:0.851),更年期/生殖寿命的年龄表现出了J形的关联.
结论:
- 初潮时的年龄,更年期时的年龄,第一次活产时的年龄,生殖寿命,流产次数和性别平等与老年女性的脆弱性有显著的关联.
- 这些生殖因素代表了脆弱性预防策略的潜在目标.
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