在巴西的兽医医院中,从狗和猫中分离出抗万科米辛耐药性肠球菌 (VRE)
Ricardo Antonio Pilegi Sfaciotte1, Leandro Parussolo2, Fernanda Danielle Melo3
1Centro de Diagnóstico Microbiológico Animal, Centro de Ciências Agroveterinária, Universidade do Estado de Santa Catarina, Avenida Luiz de Camões, n°2090, Lages, SC, 88520-000, Brazil. ricardo.sfaciotte@udesc.br.
BMC veterinary research
|February 24, 2025
概括
在46只动物中发现了抗万科素的Enterococcus (VRE) 殖民,其中vanA基因是最常见的. 这一发现突显了物中VRE的公共卫生风险和潜在的动物传播.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 一个健康,一个健康.
背景情况:
- 有限的数据存在于兽医中对万科米辛耐药性肠球菌 (VRE),特别是在狗和猫.
- 在动物中经常检测到多种耐药性肠球菌,这引发了对动物感染潜力的担忧.
- 了解兽医环境中的VRE患病率对于公众健康至关重要.
研究的目的:
- 为了识别入住兽医医院的VRE殖民动物.
- 确定Enterococcus分离物中主要的万科米辛耐药基因 (vanA,vanB,vanC,vanE) 的流行率.
- 评估Enterococcus分离物的抗菌素耐药性模式.
主要方法:
- admitted to a veterinary hospital for VRE colonization. admitted to a veterinary hospital for VRE colonization. 在兽医医院接受用于VRE殖民的动物的查. 在兽医医院接受用于VRE殖民的动物的查.
- 使用PCR. 分子检测菌素耐药基因 (vanA,vanB,vanC,vanE) 的方法.
- 对Enterococcus分离物的抗微生物敏感性测试.
主要成果:
- 在46只动物中检测到VRE殖民,其中16只是健康的携带者.
- 范A基因是最常见的 (52.54%),其次是范B (23.73%),范C (20.34%) 和范E (3.39%).
- 84.75%的Enterococcus分离物具有多药性耐药性,对恩罗夫洛克萨,利芬素和西普罗夫洛克萨具有高耐药性.
结论:
- 在巴西,VanE基因首次在一只狗身上被发现.
- 物中存在VRE和高水平氨基糖化物耐药性 (HLAR) Enterococcus的存在对公众健康造成了重大关注.
- 动物的VRE殖民增加了环境传播的风险,并对健康产生了重大影响.
相关概念视频
00:57Antibiotic Selection
49.0K
Overview
49.0K
01:28Antimicrobial Effectiveness
2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K
01:30Development of Antibiotic Resistance
2.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K
01:18Bacterial Gastroenteritis
92
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
92
01:25Mechanism of Antibiotic Resistance in MRSA
245
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
245
01:25Clinical Significance of Antibiotic Resistance
106
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
106