老年营养风险指数与老年重症患者的败血症之间的关系:一项回顾性队列研究
Yujiao Jin1, Tianyun Zhou2, Chenshu Hou2
1Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hengbu Street 2#, Hangzhou, Zhejiang, China.
European journal of medical research
|February 25, 2025
概括
老年人营养风险指数 (GNRI) 显示,老年ICU患者与败血症存在U形联系. 低和高的GNRI分数都表明患有败血症的风险更高.
科学领域:
- 老年医学 老年医学
- 临界护理医学 临界护理医学
- 营养科学 营养科学
背景情况:
- 败血症对老年重症患者构成重大威胁.
- 营养状况是影响重症监护中的患者结果的关键因素.
- 老年营养风险指数 (GNRI) 是评估老年人营养状况的验证工具.
研究的目的:
- 调查老年营养风险指数 (GNRI) 与败血症发病率之间的关系.
- 要确定这种关系在老年ICU患者中是线性的还是非线性的.
- 探索GNRI作为这一群体中败血症预测标记物的潜力.
主要方法:
- 分析了来自MIMIC-IV数据库的3,535名老年患者 (≥65岁) 的数据.
- 使用血清白蛋白,身高和体重来计算GNRI.
- 用多变量逻辑回归和受限立方线来评估GNRI和败血症之间的关联.
主要成果:
- 其中56.7%的患者发生了败血症.
- 败血症患者的GNRI值显著降低,营养不良风险的患病率更高.
- 在GNRI和败血症之间观察到U形的关联,转折点在105.4.4.
结论:
- 在老年重症患者中,GNRI和败血症风险之间存在U形关系.
- 非常低和非常高的GNRI得分都与败血症风险增加有关.
- GNRI可以作为一种有价值的查工具,用于识别患有败血症风险的老年ICU患者.
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