从MASH到肝硬化:弥合MASLD管理中的差距
Zouhir Gadi1,2, Wilhelmus J Kwanten1,2, Luisa Vonghia1,2
1Department of Gastroenterology and Hepatology, Antwerp University Hospital (UZA), Antwerp, Belgium.
Acta clinica Belgica
|February 25, 2025
概括
代谢功能障碍相关的脂肪肝炎 (MASH) 是一种严重的肝病,与代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 了解MASH的进展是改善诊断和治疗这个日益严重的全球健康问题的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 胃肠病学 胃肠病学
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 是一种严重的代谢功能障碍相关的脂肪性肝病 (MASLD).
- MASH显著增加了肝硬化,肝细胞癌 (HCC) 和与肝脏有关的死亡率的风险.
- 目前对MASH病理生理学和进展到晚期肝病的理解仍然不完整.
研究的目的:
- 审查有关MASH病理生理学的当前知识.
- 探索MASH的临床管理和先进的治疗策略.
- 突出代谢功能障碍和肝病进展之间的相互作用.
主要方法:
- 文献综述侧重于MASH病理生理学,临床管理和治疗.
- 评估治疗选择,包括改变生活方式,手术和药物治疗.
- 讨论代谢功能障碍,门高血压和HCC在MASH进展中的作用.
主要成果:
- MASH代表了MASLD进展的关键,高风险阶段.
- 关键因素包括代谢功能障碍,门高血压,脱补偿和HCC发展.
- 目前的治疗方法范围从生活方式干预到肝移植.
结论:
- 解决MASH需要更深入地了解其病理生理学和多学科的护理方法.
- 综合努力,包括先进的诊断和新的治疗方法是必不可少的.
- 改善患者的治疗结果需要解决MASLD中复杂的代谢和肝脏相互作用.
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