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Updated: May 26, 2025

Detection of Tilapia Lake Virus Using Conventional RT-PCR and SYBR Green RT-qPCR
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Detection of Tilapia Lake Virus Using Conventional RT-PCR and SYBR Green RT-qPCR

Published on: November 10, 2018

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鱼湖病毒核蛋白与RNA结合的结构

Benoît Arragain1, Martin Pelosse1, Karine Huard1

  • 1European Molecular Biology Laboratory, EMBL Grenoble, 71 Avenue des Martyrs, CS 90181, 38042, Grenoble Cedex 9, France.

Nucleic acids research
|February 25, 2025
PubMed
概括

提拉皮亚湖病毒核蛋白 (NP) 结构揭示了在 Articulavirales 序列内保存的 RNA 结合机制. 这一发现为病毒复制和相关病毒的潜在治疗点提供了洞察力.

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Viral Structure

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Nucleic Acid Structure

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Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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