相关实验视频
Updated: May 26, 2025

04:01
Transurethral Instillation Procedure in Adult Male Mouse
Published on: November 2, 2017
15.5K
系统性炎症和结肠微环境的炎症背景由乌罗立A改善
Marmar R Moussa1,2, Nuoxi Fan1, John Birk3
1Center for Molecular Oncology, School of Medicine, University of Connecticut, Farmington, Connecticut.
Cancer prevention research (Philadelphia, Pa.)
|February 25, 2025
概括
核桃的消费,富含ellagitannins,影响肠道细菌产生urolithins. 较高的乌罗林A水平与减少的炎症标志物和结肠多细胞中免疫细胞模式的改变相关,这表明癌症预防的好处.
科学领域:
- 营养免疫学 营养免疫学
- 癌症预防研究 癌症预防研究
- 肠道微生物组的新陈代谢
背景情况:
- 饮食中的多,特别是来自核桃中的多,显示出预防癌症的潜力.
- 核桃含有埃拉基坦宁,通过肠道微生物群代谢成乌罗利.
- 乌罗立代谢对炎症和癌症风险的影响需要阐明.
研究的目的:
- 为了研究urolithin代谢对血液和结肠多组织中的炎症标志物的影响.
- 为了评估核桃消费对尿路urolithins,血清炎症标记物和多免疫细胞概况的影响.
- 探索核桃消费对结肠健康和癌症预防的个性化营养方面.
主要方法:
- 临床研究涉及39名食用核桃的受试者,分析了泌尿尿酸,血清炎症标记物和多组织免疫细胞.
- 代谢数据,血清炎症标记物和多组织空间成像 (成像质细胞计) 的综合计算分析.
- 尿液和便样本的LC/MS-MS分析,以确定urolithin代谢物及其形成能力.
主要成果:
- 在形成九种乌洛的代谢产物的能力上存在显著的个体间差异.
- 较高的乌罗素A形成与较低水平的关键血清炎症标志物 (例如C-,sIL-6R) 和增加的YY相关.
- 乌罗立A与结肠多组织中维门和CD163的减少表达以及免疫细胞聚类的改变有关.
结论:
- 将埃拉基坦宁代谢成乌罗氨酸A的能力与减少炎症有关.
- 核桃的消费表明对血清炎症标志物和多细胞免疫成分的功能益处.
- 研究结果支持将核桃ellagitannins用于预防癌症的饮食,强调个性化营养的作用.
更多相关视频
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
114
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
114
Drugs for Treatment of Ulcerative Colitis in IBD
118
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
118
Inflammatory Bowel Disease IV: Pharmacological Management
89
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
89
Chronic Bowel Disorders: Introduction
378
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
378
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
295
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
295
Irritable Bowel Syndrome I: Introduction
219
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
219

