在过去的十年 (2014年至2024年) 中,1,4-二氨酸的合成演变
Hemant Kumar Rundla1, Shivani Soni1, Sunita Teli1
1Department of Chemistry, Mohanlal Sukhadia University Udaipur Rajasthan 313001 India shikhaagarwal@mlsu.ac.in lokeshkumar@mlsu.ac.in hema00886@gmail.com.
RSC advances
|February 25, 2025
概括
通过各种有机反应合成的1,4-索 (1,4-BT) 衍生物表现出广泛的生物活性. 本综述详细介绍了对1,4-BTs的合成策略,这对药物发现和药物化学至关重要.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 异环化学 异环化学
背景情况:
- 1,4-Benzothiazine (1,4-BT) 是一种具有和硫的和酸盐环的异环基架,含有和硫.
- 它独特的结构增强了生物特性,使其对药物设计和各种工业应用具有价值.
- 1,4-BT衍生物具有广泛的生物活性,包括抗精神药物,抗病毒,抗微生物和抗炎作用.
研究的目的:
- 审查和总结各种合成方法来制备1,4-Benzothiazine衍生物.
- 突出了既定和各种合成方法来访问1,4-BT核心结构.
- 为科学界提供综合策略的全面概述.
主要方法:
- 总结了已知反应,例如那些涉及2-aminothiophenol (2-ATP) 与各种基质,如基因,酶氨和二乙烯化合物.
- 概述了用于1,4-BT制备的各种合成途径.
- 讨论在各种反应条件下使用各种催化剂,包括纳米催化剂和金属基催化剂.
主要成果:
- 该审查巩固了1,4-BTs的众多合成途径.
- 介绍了使用不同催化剂和条件的高效合成方法.
- 强调了1,4-BTs在容纳各种功能方面的多功能性.
结论:
- 1,4-西亚的合成对于开发具有显著生物活性的化合物至关重要.
- 对合成路径的全面理解有助于在药物和有机化学领域的进一步进展.
- 本综述是研究人员探索1,4-BTs的合成和应用的宝贵资源.
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