葡萄糖法因因转化为硫福拉和相关化合物由肠道微生物群
Tetiana R Dmytriv1,2, Oleh Lushchak1,2, Volodymyr I Lushchak1,2
1Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
Frontiers in physiology
|February 25, 2025
概括
来自十字花蔬菜的葡萄糖法因被肠道微生物转化为硫福拉,可以对抗氧化应激和炎症. 这种相互作用突出显示了肠道微生物群.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 葡萄糖酸葡萄糖,在十字花类蔬菜中发现,是像硫福拉这样的异基酸盐的前体.
- 硫氨酸激活Nrf2信号,这对于对氧化应激的适应性反应至关重要.
- 哺乳动物的米洛西纳酶使硫福拉无活化;肠道微生物群在缺乏葡萄糖时代谢葡萄糖.
研究的目的:
- 审查葡萄糖,硫和肠道微生物群之间的双向相互作用.
- 探索硫福拉在肠道健康和恒温的作用.
- 调查异硫酸盐在支持肠道屏障功能的潜力.
主要方法:
- 关于葡萄糖甲胺代谢和肠道微生物群相互作用的研究文献综述.
- 对Nrf2信号通路和氧化应激的研究分析.
- 检查有关硫福拉对肠道微生物群组成和功能影响的证据.
主要成果:
- 肠道微生物群将葡萄糖胺代谢成各种生物活性化合物,包括硫黄和埃鲁.
- 微生物群的组成会影响葡萄糖胺代谢的效率和结果.
- 硫福拉可能调节肠道微生物群,可能缓解肠道炎症和氧化应激.
结论:
- 饮食中的葡萄糖,其代谢物 (如硫) 和肠道微生物群之间存在复杂的相互作用.
- 硫福拉在维持肠道平衡,屏障完整性和打破氧化应激和失生症循环方面显示出潜力.
- 饮食中的异硫酸盐可以作为支持肠道健康的治疗策略.
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