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Updated: May 26, 2025

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调查症状性磁盘退行症的表观遗传景观:一个案例研究

Taylor D Yeater1, Yuya Kawarai2, Seunghwan Lee1

  • 1Department of Anesthesiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.

Pain reports
|February 25, 2025
PubMed
概括

在疼痛性和非疼痛性脊椎间盘 (IVD) 之间发现了DNA甲基化差异. 这种表观遗传失调可能解释了为什么一些退化的IVD会导致腰部疼痛 (LBP),这表明了新的治疗点.

关键词:
背部疼痛 背部疼痛通过DNA甲基化.唱片记录 唱片记录 唱片记录椎间盘之间的椎间盘.脊柱 脊柱 脊柱 脊柱 脊柱 脊柱

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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