冠状动脉微血管功能障碍妇女视网膜微血管密度降低:试点研究
Sakshi Shiromani1, Ahmed AlBadri2, Aaron Lindeke-Myers3
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.
American heart journal plus : cardiology research and practice
|February 25, 2025
概括
没有阻塞性冠状动脉疾病 (INOCA) 和冠状动脉微血管功能障碍 (CMD) 的缺血妇女表现出视网膜微血管密度降低. 在INOCA患者中,非侵入性视网膜成像可能反映冠状动脉微血管功能.
科学领域:
- 心血管研究研究心血管研究
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
背景情况:
- 没有阻塞性冠状动脉疾病 (INOCA) 的缺血经常与冠状动脉微血管功能障碍 (CMD) 相关,这表明更广泛的系统性血管功能障碍.
- 反映心血管风险因素的视网膜微血管和CMD之间的关系尚不清楚.
研究的目的:
- 在被诊断为INOCA的妇女中调查和比较视网膜微血管密度,区分有CMD和没有CMD的女性.
- 探索非侵入性视网膜成像作为冠状动脉微血管功能的生物标志物的潜力.
主要方法:
- 一项涉及18名患有INOCA的女性进行的横截面研究,她们接受了冠状动脉功能测试.
- 参与者被分为CMD (冠状动脉流量储量<2.5) 和非CMD组.
- 视网膜光学连贯性断层扫描血管学用于视网膜微血管的非侵入性评估.
主要成果:
- 与非CMD组 (N=7) 相比,CMD组 (N=11) 的视网膜血管密度 (20.9对21.6,p=0.006) 和内 perfusion 密度 (38.5对41.2,p=0.006) 显著较低.
- 没有观察到群体之间的状血管区域 (FAZ) 区域,周围或圆形度的显著差异.
- 人口和临床特征,包括年龄和心血管风险因素,在CMD和非CMD组之间得到了很好的平衡.
结论:
- 与没有CMD的女性相比,患有INOCA和CMD的女性表现出视网膜微血管和 perfusion 密度的降低.
- 非侵入性视网膜成像是一种可行的,负担得起的方法,可能与INOCA患者的冠状动脉微血管功能相关.
- 需要对包括男性参与者在内的更大队列进行进一步的研究,以验证这些发现.
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