肠道微生物群和瘤免疫微环境之间的相关性:一项书目测量和可视化研究
Zheng-Jun Hu1, Hui-Rong Zhu2, Yong-Jie Jin1
1Department of Oncology, Shanghai Jiading District Hospital of Traditional Chinese Medicine, Shanghai 200000, China.
World journal of clinical oncology
|February 25, 2025
概括
这份图书统计分析显示,自2019年以来,肠道微生物群和瘤免疫微环境 (TIME) 研究的激增. 中国在出版物方面处于领先地位,而美国则表现出最有影响力,免疫疗法成为一个关键的研究重点.
科学领域:
- 研究微生物学,免疫学和瘤学的交叉点.
- 使用文献计量分析来绘制肠道微生物群和瘤免疫微环境 (TIME) 的科学景观.
背景情况:
- 越来越多的证据将肠道微生物组成与瘤免疫微环境 (TIME) 联系起来.
- 缺乏系统的文献计量研究,以全面评估这一研究领域.
研究的目的:
- 提供关于肠道微生物群和TIME的全球研究的文献统计概述.
- 确定该领域的领先国家,机构,研究人员和新兴研究主题.
主要方法:
- 从Web of Science核心集合 (2014-2024) 中对491篇出版物的图书统计分析.
- 利用CiteSpace,VOSviewer和R进行国家,机构,作者和关键词的数据可视化和分析.
主要成果:
- 从2019年开始,出版物数量迅速增加.
- 中国和美国是最多产的国家;美国表现出最高的影响力.
- 关键的研究热点包括"肠道微生物群"",瘤微环境"和"免疫疗法".
结论:
- 肠道微生物群和TIME研究领域在过去十年里大幅扩大.
- 未来的研究应该专注于特定的肠道微生物,它们的代谢物,以及它们对免疫细胞和免疫疗法疗效的影响.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.