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细菌微生物组通过影响肠-脑轴来调节大脑转移的开始

Matteo Massara^1,2,3,4, Michelle Ballabio^1,2,3,4, Bastien Dolfi^1,2,3,4

¹Department of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.

|February 25, 2025

概括

肠道微生物组对大脑瘤的发展产生负面影响. 抗生素治疗改变了包括Alistipes在内的肠道细菌,并减少了金酸,可能改善了大脑转移的结果.

科学领域:

在瘤学瘤学.
微生物学微生物学
神经科学是一个神经科学.

背景情况:

大脑转移 (BrM) 是最常见的内瘤,与患者预后不佳有关.
了解影响BrM生物学的系统和环境因素对于开发有效的治疗方法至关重要.

研究的目的:

调查肠道微生物组在乳腺BrMs的发展中的作用.
探索抗生素治疗和BrM进展对肠-大脑轴的影响.

主要方法:

在无细菌和抗生素治疗条件下使用体内乳腺BrM模型.
分析了肠道微生物群的组成,专注于细菌属Alistipes.
量化了循环中的代谢物,特别是酸,并进行了ex vivo功能测试.

主要成果:

发现肠道微生物群可以促进BrM的启动.
抗生素治疗和BrM进展改变了细菌属Alistipes的丰富性.
氨酸水平发生显著变化,并影响了癌细胞与大脑血管系统的相互作用.

结论:

肠道微生物群在乳腺BrM发育中起着不利的作用.
肠-大脑轴受微生物代谢物如金酸的影响,是管理大脑转移的潜在治疗点.

关键词:

癌症癌症癌症癌症微生物组是一个微生物组.微观环境是一个微观环境.

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