在老年人群中,泛免疫炎症值与冠心病之间的关联:一个横截面研究
Ruicong Ma1, Jinyi Ren2, Xianmei Chen2
1Department of Cardiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
全免疫炎症值 (PIV) 与冠心病 (CHD) 有关,特别是在老年人中. 将PIV与控制营养状况 (COUNT) 评分相结合,可以改善心脏病诊断.
科学领域:
- 心血管医学 心血管医学
- 炎症和免疫学 炎症和免疫学
- 老年病的医生 老年病的医生
背景情况:
- 系统性炎症,免疫状况和营养是冠心病 (CHD) 发展的关键因素.
- 全免疫炎症值 (PIV) 为评估系统性炎症和免疫反应提供了一种新型指标.
- 了解PIV和CHD之间的关系,特别是在老年人中,对于早期检测和管理至关重要.
研究的目的:
- 调查PIV与CHD在大量人口队列中的患病率之间的关联.
- 确定PIV是否对心脏病具有诊断价值,特别是在老年人 (60岁及以上) 中.
- 评估PIV的综合诊断疗效和控制营养状况 (COUNT) 评分对心脏病的评价.
主要方法:
- 来自NHANES数据库 (1999-2018) 的41,713名参与者的数据分析.
- 使用后勤回归和受限立方线模型来评估PIV和CHD之间的关系.
- 用接收器操作员特征 (ROC) 曲线来评估PIV和PIV-COUNT得分组合的诊断性能.
主要成果:
- 在患有心脏病的人群中观察到更高的PIV水平,这表明了积极的关联.
- 确定了PIV和CHD之间的显著正非线性相关性,主要在老年人群中 (≥60岁).
- 结合PIV和COUNT得分,与单独的标志物或其他炎症指标相比,CHD的诊断价值更高.
结论:
- PIV与心血管疾病有积极的关联,在老年人中观察到的效果更为明显.
- PIV为心脏病提供了显著的诊断潜力,优于其他常见的炎症标志物.
- 将PIV与COUNT得分相结合,可以提高心脏病的诊断准确度,这表明它是风险分层的有价值的临床工具.
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