相关实验视频

Updated: Sep 30, 2026

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

Published on: December 18, 2017

来自代谢功能障碍相关的乳脂性肝炎的十二指管器官患者表现出吸收和屏障变化

Alia Hadefi^1,2,3, Morgane Leprovots¹, Gilles Dinsart¹

¹IRIBHM, Jacques E. Dumont, Faculty of Medicine, Université Libre de Bruxelles ULB, Brussels, Belgium.

Gastro hep advances

|February 25, 2025

概括

代谢功能障碍相关的脂肪肝炎 (MASH) 改变十二指甲状腺上皮细胞,影响营养吸收和细胞结合. 这些发现揭示了对MASH病原体和潜在的肠道向疗法的新见解.

科学领域:

胃肠病学和肝病学
细胞生物学细胞生物学
代谢疾病代谢疾病

背景情况:

代谢功能障碍相关的脂肪肝炎 (MASH) 是一种与代谢风险因素相关的渐进性肝病.
肠肝轴在MASH病变发生过程中越来越被认可,但人类十二指肠表皮的研究是有限的.

研究的目的:

为了调查MASH患者十二指甲上皮的内在功能障碍.
探索MASH十二指肠细胞中营养吸收和屏障功能的变化.

主要方法:

从MASH患者和健康对照中生成的十二指甲状腺上皮器官.
分析了转录组,并对患者衍生器官进行了功能测试.
评估了十二指甲上皮的吸收潜力和屏障功能.

主要成果:

来自MASH的十二指甲上皮器官 (MDEO) 显示了改变的消化潜力和减少成熟的吸收细胞命运.
MDEO保留了脂质代谢能力,可能是通过干细胞/原始细胞的脂质氧化.
尽管连接蛋白的表达错误,但MDEO保持了屏障完整性.

结论:

在MASH患者的十二指上皮表现出与营养相关功能的显著变化.
十二指甲上皮细胞的变化为MASH提供了潜在的治疗点.
这项研究强调了肠肝轴在MASH病理生理学中的作用.

关键词:

细胞粘附细胞粘附肠道肠道肠道马什 (MASH) 是一个非常重要的产品.器官类动物器官类动物干细胞是干细胞.

更多相关视频

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids

Published on: October 13, 2019

Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function

Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function

Published on: July 29, 2021

相关概念视频

Histology of the Small Intestine

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...