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借用气/奇拉胺继电催化使酒精的二元选择性β-C-H功能化成为可能

  • 0Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.

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A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
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The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.

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If a set of reactants can yield multiple constitutional isomers, but one of the isomers is obtained as the major product, the reaction is said to be regioselective. In such reactions, bond formation or breaking is favored at one reaction site over others.
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The chiral α-carbon of the carbonyl compound is the stereocenter of the molecule. As shown in the figure below, when such a carbonyl compound undergoes racemization under an acidic or basic condition, an achiral enol is formed.

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