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相关概念视频

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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一个3D打印的光学显微镜用于低成本的组织学成像.

Jay Christopher1, Rebecca Craig2, Rebecca E McHugh3

  • 1Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK.

Journal of microscopy
|February 25, 2025
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概括

研究人员开发了一种低成本的3D打印光学显微镜. 这种可访问的诊断成像工具实现了亚细胞分辨率,证明了其广泛使用的潜力.

关键词:
添加剂制造 添加剂制造 添加剂制造诊断成像诊断成像的使用.显微镜 显微镜是指使用显微镜.开放式显微镜的使用方法光学是什么?光学是什么?光学是什么?

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科学领域:

  • 生物医学工程 生物医学工程
  • 光学显微镜的使用方法
  • 3D打印技术的使用

背景情况:

  • 传统的光学显微镜昂贵而复杂,在资源有限的环境中限制了可访问性.
  • 3D打印为低成本制造定制光学元件和显微镜底盘提供了一条途径.

研究的目的:

  • 设计,制造和描述一个完全3D打印的低成本光学显微镜.
  • 为了证明使用3D打印光学来实现诊断级成像的可行性.
  • 提供开源设计,方便复制和定制.

主要方法:

  • 使用化沉积建模 (FDM) 3D打印制造显微镜底盘和目标镜头.
  • 集成一个基本的摄像头和拉斯伯派控制的LED照明系统.
  • 使用标准测试目标和组织学样本 (血液涂抹,小鼠部) 进行表征.

主要成果:

  • 成功制造了一种功能性光学显微镜,采用3D打印的镜头 (2.9×放大,NA 0.07).
  • 达到亚细胞分辨率,使红细胞和脏组织细节的可视化.
  • 与商业明亮场显微镜相比,经过证明的成本效益.

结论:

  • 3D打印的显微镜为诊断成像提供了一个可行的,低成本的替代方案.
  • 该设计展示了增材制造在创建可访问的科学仪器的潜力.
  • 进一步的定制和在各种诊断成像场景中的应用是高度可行的.