捕捉重要的事情:患者报告的LGI1-ANTibody脑炎结果评级表 (LANTERN)
Mark J Kelly1,2,3, Barbara Wagner1,4, Bryan Ceronie1,3
1Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Annals of clinical and translational neurology
|February 25, 2025
概括
一个新的患者报告的结果指标,LANTERN尺度,有效量化LGI1抗体脑炎的持续症状. 这种工具有助于了解LGI1-Ab-E患者的临床医生评级之外的真正的症状负担.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 患者报告的结果
背景情况:
- LGI1抗体脑炎 (LGI1-Ab-E) 往往具有良好的临床医生评级结果,但许多患者经历了长期的衰弱症状.
- 现有的评估可能无法完全捕捉LGI1-Ab-E患者经历的持续症状负担.
研究的目的:
- 开发和验证LGI1-抗体脑炎评分 (LANTERN) 尺度,一种疾病特异性患者报告的结果指标 (PROM).
- 量化LGI1-Ab-E中症状的频率和严重程度以及对日常生活的影响.
主要方法:
- 一种由参与者驱动的三阶段混合方法方法方法,包括采访,认知汇报和心理测量调查.
- 开发涉及从73个初始项目生成项目,与15名参与者进行认知汇报,并与66名患者和32名亲属进行最终调查.
- 分析包括探索性因子分析,敏感性测试和多次内部/外部验证.
主要成果:
- 兰特纳尺度被提炼成41个问题调查,评估19个症状和6个日常生活活动 (ADL) 在身体,认知/行为和ADL领域.
- 最后的问卷显示了强大的内部可靠性 (克朗巴赫α:0.85-0.91) 和优异的测试-重新测试相关性 (0.81-0.98).
- 观察到与相对填写的问卷 (R=0.73-0.85) 和预定义的外部措施有很高的相关性.
结论:
- 兰特尺度是LGI1-Ab-E的有效和可靠的PROM,具有初始内容,结构和构造有效性.
- 它提供了一个量身定制,高效和敏感的方法来评估LGI1-Ab-E患者的症状负担.
- LANTERN适用于临床实践和临床试验,以更好地了解患者的体验.
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