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母体甲状腺蛋白抗体与优甲状腺妇女早产的关联
Shuai Yang1,2,3, Zixuan Huang1,2,3, Yong Zhang1,2,3
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
The Journal of clinical endocrinology and metabolism
|February 25, 2025
概括
甲状腺蛋白抗体 (TgAb) 阳性在乳甲状腺孕妇中与早产 (PTB) 的风险增加有关,特别是自发和晚期PTB. 这种关联在具有较低TSH水平的女性中最为显著.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 生殖免疫学 生殖免疫学
背景情况:
- 母体甲状腺过氧化酶抗体 (TPOAb) 阳性是早产 (PTB) 的已知危险因素.
- 铁血球蛋白抗体 (TgAb) 和PTB风险在平甲状腺妇女之间的关联仍然不清楚.
- 了解与PTB的抗体关联对于孕产妇和胎儿健康结果至关重要.
研究的目的:
- 为了研究TgAb阳性和PTB风险之间的关系,在euthyroid孕妇.
- 探索TgAb是否是PTB及其亚型的独立风险因素.
- 检查甲状腺刺激激素 (TSH) 水平对TgAb-PTB关联的影响.
主要方法:
- 一项前性队列研究,对58247名在第一季度的甲状腺功能良好的女性进行了前性队列研究.
- 测量了血清中的TgAb,TPOAb,TSH和FT4水平.
- 分析了整体的PTB和亚型 (自发性,医疗诱导,早期,晚期),后勤回归和TSH分层.
主要成果:
- TgAb阳性与PTB风险增加16%有关 (aOR为1.16,95%CI为1.03-1.29)).
- 特别地,TgAb阳性与自发PTB (aOR 1.22) 和晚期PTB (aOR 1.17) 的更高风险有关.
- 这些关联在第一季度TSH水平在0.1-2.5mIU/L之间的女性中是显著的.
结论:
- 无甲状腺女性的TgAb阳性与PTB风险增加有关,主要是自发和晚期PTB.
- 这些发现表明TgAb可能在PTB发展中发挥作用,特别是在低TSH的女性中.
- 需要进一步的研究来澄清临床意义和潜在机制.
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