心理社会因素的性别差异和慢性冠状动脉疾病患者的胸痛
Anaïs Hausvater1, Rebecca Anthopolos2, Alexa Seltzer1
1Department of Medicine, Cardiovascular Clinical Research Center, Leon H. Charney Division of Cardiology NYU Grossman School of Medicine New York NY USA.
Journal of the American Heart Association
|February 25, 2025
概括
高压力和抑郁症状独立地使心痛和健康状况在患有冠状动脉疾病 (CAD) 或无阻塞性CAD (INOCA) 缺血的男性和女性中恶化. 其他因素也会导致女性的结果更差.
科学领域:
- 心脏病学 心脏病学
- 精神病体医学是一种精神病体医学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 患有慢性冠状动脉疾病 (CAD) 的女性比男性更频繁地经历心痛和更糟糕的健康状况,尽管他们有较少的阻塞性CAD.
- 研究感知到的压力和抑郁症状在心痛中性别差异中的调解作用至关重要.
- 了解阻塞性冠状动脉疾病和没有阻塞性冠状动脉疾病 (INOCA) 的缺血症中的这些差异很重要.
研究的目的:
- 为了检查是否感知到的压力和抑郁症状调解性差异与胸痛相关的健康状况.
- 要确定这种关系是否在阻塞性CAD和INOCA之间有所不同.
主要方法:
- 对ISCHEMIA试验和CIAO-ISCHEMIA辅助研究数据的分析.
- 评估感知到的压力 (感知到的压力量-4) 和抑郁症状 (患者健康问卷-8).
- 使用西雅图心痛问卷 (SAQ) 评估心痛相关的健康状况.
主要成果:
- 在CAD和INOCA队列中,女性报告的SAQ得分比男性更差.
- 在这两组中,更高的压力和抑郁症状与更严重的胸痛有关.
- 女性性别,压力和抑郁症独立地与较差的SAQ分数有关,但CAD与INOCA队列并不是一个重要因素.
结论:
- 高压力和抑郁症状独立地与患有或没有阻塞性心血管疾病的患者的胸痛恶化和健康状况恶化有关.
- 这些心理因素与性行为没有相互作用,从而影响健康状况.
- 除了压力和抑郁之外,其他因素也会导致阻塞性CAD或INOCA的妇女的健康状况较差.
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