基于四糖酸盐,奇托桑化物和葡萄甘的甘油的制备和性能
Sergei L Shmakov1, Olga S Ushakova1, Marina A Kalinicheva1
1Chair of Polymers, Institute of Chemistry, Saratov State University, 83 Astrakhanskaya St., 410012 Saratov, Russia.
Gels (Basel, Switzerland)
|February 25, 2025
概括
使用天然葡萄甘 (GM) 和酸盐 (CS) 的新型甘油提供快速凝 (<2分钟) 和强大的粘液/皮肤粘合,适用于液体带等生物医学应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 基于甘酸盐,奇托 (CS) 和聚乙烯醇 (PVA) 的甘油被确立为生物医学用途.
- 越来越多的趋势是用天然的替代品来取代像PVA这样的合成聚合物,例如葡萄康南 (GM).
- 功能添加剂对于定制水凝特性至关重要,包括凝时间.
研究的目的:
- 综合研究新型糖凝的制备和特性.
- 在基于糖酸盐和酸盐化物 (CS·HCl) 的水凝中用葡萄甘 (GM) 取代PVA.
- 调查各种因素对凝时间的影响,并评估粘粘性和皮肤粘性.
主要方法:
- 粘度测量被用来评估CS·HCl和GM大分子及其溶液中的同伴的构成状态.
- 用船体逆转法确定凝动力学.
- 粘膜粘合和皮肤粘合性能通过从模型基板撕裂的方法来评估.
主要成果:
- 估计了单个聚合物及其混合协同物的构造状态,并计算了内在粘度和水力动力半径.
- 影响凝时间的因素包括酸度,离子强度 (调整为e-aminocaproic acid,HCl,NaCl,NaOH,四),温度和奇托分子量.
- 达到的凝时间不到2分钟,具有与商业产品相比的优异粘膜粘合和皮肤粘合.
结论:
- 合成的基于四甘油酸盐,CS·HCl和GM的甘油凝表现出快速凝和强大的粘合性.
- 这些新型水凝显示出诸如液体带和其他生物制药用途等应用的潜力.
- 这些发现支持在先进的生物材料开发中将合成聚合物替换为天然多糖.
关键词:
氨基烯酸是氨基烯酸的一种生物粘合性质 生物粘合性质基多酸盐的使用方法凝凝是一种凝.葡萄康曼南 (Glucomannan) 是一种葡萄素.糖水凝的使用方法糖酸盐是什么 糖酸盐是什么四乙酸盐是什么意思更多相关视频
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