Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

627
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
627
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

895
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
895
T Cell Types and Functions01:24

T Cell Types and Functions

830
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
830

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Myeloid-Derived Suppressor Cells in Inflammatory Arthritis.

International journal of molecular sciences·2026
Same author

Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Longitudinal peripheral blood multi-omic profiling in seropositive individuals identifies immune endotypes and predictive models for future rheumatoid arthritis conversion.

medRxiv : the preprint server for health sciences·2026
Same author

TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy.

Cellular & molecular immunology·2026
Same author

Soluble CD13 in systemic sclerosis: clinical observations and transcriptomic insights from peripheral blood.

Arthritis research & therapy·2026
Same author

Spatial transcriptomics uncovers lipid metabolic dysregulation driving immune-stroma crosstalk in Sjögren's Disease.

EBioMedicine·2025
Same journal

RETRACTED: Bakshi et al. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. <i>Cells</i> 2022, <i>11</i>, 1502.

Cells·2026
Same journal

Correction: Verde et al. Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses. <i>Cells</i> 2025, <i>14</i>, 680.

Cells·2026
Same journal

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cells·2026
Same journal

IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.

Cells·2026
Same journal

Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria.

Cells·2026
Same journal

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026
查看所有相关文章

相关实验视频

Updated: May 26, 2025

Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

12.6K

人类疾病中的CD6.

Mikel Gurrea-Rubio1, David A Fox1, Javier S Castresana2

  • 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Cells
|February 25, 2025
PubMed
概括
此摘要是机器生成的。

CD6是一种细胞表面蛋白质,对免疫细胞功能至关重要,与自身免疫性疾病有关. 准CD6对治疗包括癌症在内的各种疾病有前途.

关键词:
CD166 是一个CD166 是一个CD166CD318 是一个CD318 是一个CD318.CD4444 是一个CD44在CD6 CD6 CD6 CD6 CD6 CD6 CD6这是自身免疫力.免疫疗法 免疫疗法

更多相关视频

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K
Generation of Human CD40-activated B cells
13:27

Generation of Human CD40-activated B cells

Published on: October 16, 2009

15.2K

相关实验视频

Last Updated: May 26, 2025

Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

12.6K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K
Generation of Human CD40-activated B cells
13:27

Generation of Human CD40-activated B cells

Published on: October 16, 2009

15.2K

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子医学是分子医学.

背景情况:

  • CD6是淋巴细胞上发现的细胞表面蛋白质,调解关键的免疫细胞相互作用.
  • 它的配体包括CD166 (ALCAM) 和CD318 (CDCP1),CD44作为潜在的新配体出现.
  • CD6在淋巴细胞激活,增殖和粘附中起着重要的作用.

研究的目的:

  • 分析CD6在15多种疾病的发病过程中的多方面的作用.
  • 在人类临床应用中审查支持CD6向治疗的当前数据.

主要方法:

  • 文献综述和对CD6功能和疾病相关性现有研究的分析.
  • 检查关于CD6-连接体相互作用及其功能后果的数据.
  • 对CD6向治疗策略的临床数据的评估.

主要成果:

  • CD6参与了许多自身免疫性疾病的发病,特别是通过其调节CD4+T细胞反应.
  • CD6相互作用对于免疫细胞的粘附和激活至关重要.
  • CD6为新型癌症免疫疗法提供了一个可行的标.

结论:

  • CD6是免疫反应的关键调节者,在疾病的发病过程中具有重要影响.
  • 向CD6为自身免疫性疾病和癌症免疫疗法提供了一个有希望的治疗途径.