在良性前列腺增生症中氧化应激:机制,临床相关性和治疗前景
Aris Kaltsas1, Timoleon Giannakas1, Marios Stavropoulos1
1Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Diseases (Basel, Switzerland)
|February 25, 2025
概括
氧化应激和炎症是良性前列腺增生症 (BPH) 进展的关键驱动因素. 用抗氧化和抗炎策略准这些因素可能会改善BPH男性的结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 病理生理学 病理生理学
- 分子生物学分子生物学
背景情况:
- 良性前列腺增生 (BPH) 是一种常见的衰老状况,导致下泌尿道症状 (LUTS).
- 虽然雄激素参与其中,但氧化应激 (OS) 和慢性炎症越来越多地被认为是BPH病变的关键因素.
- 了解OS,炎症和激素的相互作用对于BPH管理至关重要.
研究的目的:
- 审查和综合当前关于OS,炎症和BPH中的荷尔蒙调节之间的关系的研究.
- 突出针对OS和BPH炎症的临床相关性和潜在的治疗影响.
- 评估旨在缓解OS和BPH炎症的干预措施.
主要方法:
- 关于机理学研究,临床试验和观察报告的综合文献综述.
- 分析关于BPH反应性氧物种 (ROS) 生成,抗氧化能力和炎症介质的数据.
- 评估干预措施,包括抗氧化剂补充剂,抗炎药物和植物治疗药物.
主要成果:
- 长期炎症和前列腺组织的多性前列腺组织中的OS的一致证据.
- 过度的ROS和降低的抗氧化剂防御促进前列腺细胞的增殖和抑制细胞亡.
- 代谢性并发症会加剧OS和炎症;标准疗法不针对这个轴.
- 针对骨系统和炎症的新兴疗法显示出减少前列腺大小和LUTS的潜力.
结论:
- 骨系统和炎症是BPH进展的重要因素.
- 将抗氧化和抗炎策略与传统治疗相结合,可能会改善临床结果和生活质量.
- 对OS生物标志物和个性化治疗方案需要进一步的研究.
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