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Updated: May 26, 2025

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对人类PNPase在健康和疾病中的结构洞察力

Yi-Ching Li1, Chun-Hsiung Wang2, Malay Patra1

  • 1Institute of Molecular Biology, Academia Sinica, Taipei, 11529, ROC, Taiwan.

Nucleic acids research
|February 25, 2025
PubMed
概括

人类多核酸酶 (hPNPase) 突变破坏了线粒体RNA处理. 这项研究揭示了S1域灵活性是hPNPase功能的关键,以及与疾病相关的突变如何损害RNA结合和降解.

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