患有食道的新生儿的流行病学和治疗结果:一项为期30年的基于人口的研究
Tanja Kovačević1,2, Branka Polić1,2,3, Joško Markić1,2
1Department of Pediatrics, University Hospital of Split, 21000 Split, Croatia.
Healthcare (Basel, Switzerland)
|February 25, 2025
概括
在克罗地亚南部,食道缩症 (EA) 的患病率为每1万例出生中有2.44例. 2002年以后,由于儿科护理的加强,生存率显著提高,但并发症仍然是一个问题.
科学领域:
- 儿科手术 儿科手术
- 新生儿科学 新生儿科学
- 遗传性缺陷 遗传性缺陷是一种先天性缺陷
背景情况:
- 食道 (EA) 是一种罕见的先天性形,结果各不相同.
- 由于全球数据有限,因此需要进行区域研究以更好地理解.
- 克罗地亚南部的高等教育中心提供了一个独特的数据源.
研究的目的:
- 确定克罗地亚南部EA的出生总流行率.
- 分析早期治疗结果和生存率.
- 确定影响死亡率和发病率的因素.
主要方法:
- 53个EA案件 (1991-2020年) 的回顾性审查.
- 从单一的高等推中心收集的数据和背景出生数据.
- 分析新生儿状态,诊断,手术发现,并发症和结果.
主要成果:
- 平均出生率为每1万例出生中有2.44例;没有显著的性别差异.
- 在30年内,死亡率从87%降至8% (p < 0.001).
- 生产后1年的存活率为54%; 观察到高率的手术前死亡,败血症,肺炎和脱胎症.
结论:
- 南克罗地亚EA的患病率与欧洲数据一致.
- 2002年后的生存率改善与专门的儿科ICU和培训有关.
- 进一步降低死亡率需要加强早期诊断,多学科护理,感染控制和呼吸系统支持.
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