子宫微生物群和双:在生殖健康方面具有新的影响力
Dafne Castellanos-Ruiz1, J Gerardo Ojeda-Borbolla1, Olga V Ruiz-García1
1Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Journal of xenobiotics
|February 25, 2025
概括
双暴露可能会破坏女性生殖道 (FRT) 微生物群,影响胚胎植入. 了解这些影响对于评估生殖健康风险至关重要.
科学领域:
- 生殖生物学和毒理学.
- 微生物组研究的研究.
- 内分泌学 在内分泌学.
背景情况:
- 不孕症影响全球8-12%的夫妇,植入失败对早期妊娠损失作出了重大贡献.
- 暴露于内分泌干扰化学物质,如双,越来越多地与不孕率的上升有关.
- 子宫微生物群在生殖健康中发挥作用,但其与内分泌干扰物的相互作用尚未研究.
研究的目的:
- 审查目前对女性生殖道 (FRT) 微生物群及其与生殖疾病的关联的理解.
- 检查双暴露对微生物群组成和生殖健康的影响.
- 探索子宫微生物群相互作用的分子机制,对胚胎植入至关重要.
主要方法:
- 文献综述综合了关于FRT微生物群,双效应和生殖失败的现有研究.
- 在肠道和子宫环境中分析分子通路,包括托尔类受体 (TLR) 和紧结 (TJ) 蛋白质.
- 识别知识缺口和风险评估的研究需求.
主要成果:
- 已知双可以改变肠道微生物群的组成和功能.
- 紧结 (TJ) 蛋白对于胚胎植入至关重要,双暴露会破坏它们的表达和局部化.
- 虽然对双和子宫微生物群的直接研究缺乏,但从肠道微生物组研究中得出的结论表明可能存在破坏.
结论:
- 双暴露可能通过改变子宫微生物群和损害子宫植入环境而对生殖健康产生负面影响.
- 需要进一步的研究来阐明双对FRT微生物群的特定影响及其在生殖失败中的作用.
- 了解这些相互作用对于精确评估内分泌干扰剂对人类生殖的风险至关重要.
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