心力衰竭和骨质疏松症:老龄化人口的共同挑战
Roberto Spoladore1, Claudio Mario Ciampi2, Paolo Ossola2
1Heart Failure Clinic, Division of Cardiology, Alessandro Manzoni Hospital, ASST Lecco, 23900 Lecco, Italy.
Journal of cardiovascular development and disease
|February 25, 2025
概括
心力衰竭 (HF) 和骨质疏松症 (OP) 经常同时存在,使患者的预后恶化. 这篇评论探讨了它们的共同机制,强调了维生素D,PTH和FGF-23在这种双向关系中的作用.
科学领域:
- 老年医学 老年医学
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 心力衰竭 (HF) 和骨质疏松症 (OP) 经常是并发症,特别是在50岁以上的人群中.
- 同时出现的HF和OP导致患者的预后较差,而不是单独出现任何一种情况.
- 临床证据表明一种双向关系,骨折增加HF风险,HF增加骨折风险.
研究的目的:
- 综述关联心力衰竭和骨质疏松症的常见病理生理机制.
- 为了确定管理这些相互交织的条件的潜在的新治疗目标.
主要方法:
- 临床研究和病理生理机制的文献综述.
- 分析涉及维生素D,副甲状腺激素 (PTH) 和纤维细胞生长因子23 (FGF-23) 的共享途径.
- 检查导致HF患者OP的因素,反之亦然.
主要成果:
- 骨质疏松症患者因维生素D缺乏,PTH升高和FGF-23.3增加而容易患上HF.
- 肝炎患者容易患OP和骨折,原因是维生素D不足,PTH高,功能衰竭以及荷尔蒙/药物影响.
- 共同的机制包括维生素D缺乏,PTH失调和FGF-23活性.
结论:
- HF和OP之间的相互作用涉及复杂的,共享的病理生理路径.
- 专注于早期诊断和治疗的综合临床方法对于改善患者的治疗结果至关重要.
- 了解这些共同的机制可能会为这两种疾病揭示新的治疗策略.
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