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非住院的长期COVID患者表现出减少的视网膜毛细血管输液:一项前性队列研究

Clayton E Lyons¹, Jonathan Alhalel^1,2, Anna Busza¹

¹Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Journal of imaging

|February 25, 2025

概括

SARS-CoV-2 (PASC) 后急性后续影响大脑,这项研究发现Neuro-PASC患者的深毛细管血管长度密度降低. 这表明小血管损伤可能是COVID-19后神经症状的基础.

科学领域:

眼科医生眼科眼科
神经学神经学
血管生物学血管生物学

背景情况:

在SARS-CoV-2 (PASC) 后急性后续的潜在机制,特别是神经PASC,仍然在很大程度上是未知的.
研究神经PASC患者的潜在生理变化对于理解和治疗这种疾病至关重要.

研究的目的:

用光学相干断层扫描血管学 (OCT-A) 来研究非住院Neuro-PASC患者的视网膜微血管变化.
为了比较神经PASC患者和健康对照者之间的视网膜状血管区域 (FAZ),血管密度 (VD) 和血管长度密度 (VLD).

主要方法:

使用OCT-A来分析视网膜中的表面 (SCP) 和深层 (DCP) 毛细管.
测量FAZ,VD和VLD,用于FAZ的手动划分和用于VD和VLD的ImageJ宏.
采用线性混合效应模型来分析OCT-A变量,根据年龄,性别和患者特定的随机效应进行调整.

主要成果:

与健康对照组相比,神经PASC患者的DCP VLD在统计学上显著降低 (p=0.005).
两组之间没有观察到FAZ或VD的显著差异.
这些发现表明,最小的血管在深层毛细血管中可能有偏好的参与.

结论:

在Neuro-PASC患者中观察到的DCP VLD的减少表明微血管变化是神经后续的潜在机制.
这些发现强调了OCT-A在检测与神经PASC相关的微妙视网膜血管变化的实用性.
需要进一步的研究来确认这些微血管变化,并探索治疗干预措施.

关键词:

长时间的COVID.光学连贯断层扫描血管造影 (OCT-A)视网膜视网膜视网膜是一个船舶密度 (VD) 是指船舶的密度.船舶的长度密度 (VLD)

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