静脉注射非类固醇抗炎药物在临床实践中的应用:叙述性综述
Axel Maurice-Szamburski1, Cyril Quemeneur2,3, Romain Rozier4
1Department of Anesthesiology and Critical Care, Pasteur University Hospital, 06300 Nice, France.
Pharmacy (Basel, Switzerland)
|February 25, 2025
概括
静脉注射的非类固醇抗炎药物 (NSAIDs) 有效地管理术后疼痛,减少了高达60%的阿片类药物使用. 静脉输入布洛芬在成人和儿童的疼痛缓解和阿片类药物节约方面显示出有利的概况.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 静脉注射的非类固醇抗炎药物 (NSAIDs) 是手术治疗中的多模式止痛的组成部分.
- 它们对成人和儿童的术后疼痛的疗效和安全性需要目前的评估.
研究的目的:
- 审查静脉注射 (IV) NSAIDs用于外科手术期间疼痛管理的疗效,安全性和临床应用.
- 评估在欧洲批准用于治疗急性中度外科手术后疼痛的NSAID和选择性COX-2抑制剂 (coxibs).
主要方法:
- 欧洲批准的IVNSAIDs的叙事审查,包括ibuprofen,ketorolac,ketoprofen,naproxen,paracetamol和乙烯基酸.
- 分析受美国和全球指导方针和临床实践的影响.
主要成果:
- 输液NSAIDs可使术后阿片类药物消耗降低约20-60%,增强疼痛管理并最大限度地减少阿片类药物的副作用.
- 输液性易布洛芬在阿片类药物节约和缓解疼痛方面表现良好,发病速度比口服形式更快.
- 输入式布洛芬和类药物的不良事件频率似乎相似; 输入式布洛芬最好用于婴儿和无法服用口服药物的婴儿.
结论:
- 静脉注射的NSAID对于外科手术期间的疼痛管理非常有价值,可以显著减少阿片类药物的使用.
- 输液性布洛芬是一种有利的选择,特别适用于儿科患者和那些有口服管理挑战的人.
- 建议进行进一步的对比试验,比较IV NSAID,以完善临床实践.
相关概念视频
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.7K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.7K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
897
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
897
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
703
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
703
Inflammatory Bowel Disease IV: Pharmacological Management
1.1K
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
1.1K
Inflammatory Bowel Disease V: Surgical Management
926
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
926
Inflammatory Bowel Disease IV: Clinical Manifestations
64
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
64


